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Roy, Souvik
- Current Havoc of TB and its Alleviation by Green Pharmacy Discipline : Medical Biotechnology
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Authors
Affiliations
1 Post-Graduate Department of Biotechnology, St. Xavier’s College (Autonomous), 30, Mother Teresa Sarani, Kolkata -700 016, West Bengal, IN
2 Department of Microbiology, Lady Brabourne College, P-1/2, Suhrawardy Avenue, Kolkata-700 017, West Bengal, IN
1 Post-Graduate Department of Biotechnology, St. Xavier’s College (Autonomous), 30, Mother Teresa Sarani, Kolkata -700 016, West Bengal, IN
2 Department of Microbiology, Lady Brabourne College, P-1/2, Suhrawardy Avenue, Kolkata-700 017, West Bengal, IN
Source
Indian Science Cruiser, Vol 31, No 3 (2017), Pagination: 43-49Abstract
Tuberculosis (TB) remains one of the deadliest diseases of humans, with a present worldwide annual mortality rate of over a million. Global resurgence of TB, and the emergence of multi-drug resistant TB (MDR-TB) and extensively-drug resistant TB (XDR-TB) in India call for the development of new anti-tubercular drugs to combat them. Medicinal plants from the rich heritage of Indian flora, a lesser-explored area as anti-TB green pharmacy till date, offer a hope for the development of alternative medicines, necessitating their potencies to be meticulously scanned and evaluated. For the effective control of MDR-strains of Mycobacterium tuberculosis, a systematic screening of plants would be the first step in the development of a suitable phytodrug, which would also be economically viable in the medicinal plant trade. Use of such non-conventional anti-TB herbal medicines is expected to acquire brisk popularity, owing to the toxicity and overwhelming side-effects of anti-tubercular allopathic medicines. In the present review, a situation report on the on-going global efforts to discover and develop drugs from twelve selected medicinal plants have been discussed, which have ample potential as anti-TB agents, as identified from various sources in the corresponding literature reviewed.Keywords
Tuberculosis, Multi-drug Resistant TB (MDR-TB), Extensively-drug Resistant Tb (XDR-TB), Anti-tubercular Drugs, Green Pharmacy, Alternative Medicines, Phytodrug, Medicinal Plant Trade, Anti-tb Herbal Medicines.References
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- Bacteria –The New ‘magic Bullet’ Against Cancer!
Abstract Views :521 |
PDF Views:5
Authors
Affiliations
1 Department of Biotechnology
2 Department of Microbiology, St. Xavier’s College (Autonomous), 30, Mother Teresa Sarani, Kolkata -700 016, West Bengal, IN
1 Department of Biotechnology
2 Department of Microbiology, St. Xavier’s College (Autonomous), 30, Mother Teresa Sarani, Kolkata -700 016, West Bengal, IN
Source
Indian Science Cruiser, Vol 32, No 6 (2018), Pagination: 25-31Abstract
Microbes in general, as also the commensal human microbiota, are an important modulator of disease physiology of the host, including affecting cancer proliferation and progression. Cancer metastasis still remains an enigma in origin and consequence, and is one of the most important causes of morbidity and mortality of man in the recent times. A myriad of beneficial immunological effects, including the highly important anti-cancer activities, have been attributed to some specific bacteria, as also some members of the human normal microflora. Even though there is no direct experimental evidence as of now, in support of cancer suppression as a result of microbial infestation in the human body, yet, there is a wealth of indirect evidence available in the literature, which is based largely on laboratory studies, and those will grossly be revisited in the present paper. As bacteria-mediated tumour therapy (BMTT) has ample potential to evolve into the much desired ‘magic bullet’ against various types of malignancies, this paper aims to present a state-of-the-art review on applicability of bacteria as cancer therapeutics. Further, this review will delineate the selective advantages of BMTT over the conventional chemotherapeutic drugs against cancer, and will also discuss the associated challenges ahead.Keywords
Commensal Human Microbiota, Cancer Metastasis, BMTT, Magic Bullet, Malignancies, Cancer Therapeutics.References
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